L. Ignatovich, V. Muravenko, V. Romanovs, I. Sleiksha, I. Shestakova et. al. Synthesis, structure and cytotoxic activity of new 1-[5-organylsilyl(germyl)-2-furyl(thienyl)]nitro-ethenes. Appl.Organometal.Chem., 2010, 24, pp. 858-864.
http://onlinelibrary.wiley.com/doi/10.1002/aoc.1712/abstract
Kopsavilkums
New highly cytotoxic 1-[5-organylsilyl(germyl)-2-furyl(thienyl)]nitroethenes (IC500.3-3 µg ml-1) have been prepared by condensation reaction of corresponding silicon- and germanium-containing heterocyclic aldehydes with nitromethane using ammonium acetate as the catalyst. The desired nitroethenes were identified by NMR (1H, 13C and 29Si), IR, HRMS and GC-MS spectra. The structure of 1-(5-triphenylsilyl-2-thienyl)nitroethene was studied by X-ray. The influence of the substituent structure on the cytotoxicity was investigated.
